News ArticlesCD93 maintains vascular integrity and limits metastatic disseminationMetastasis formation is a multistep process that involves cancer cell transmigration through tumor vessels and through the healthy vasculature of the affected organ. This process is limited by an intact vascular barrier formed by endothelial cells, ECM, and pericytes. In a publication in JCI Insight, researchers from HPA and Uppsala University studied the role of the protein CD93 in maintaining vascular integrity in metastatic cancers...Read more Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infectionsCurrent approaches to determine molecular signatures of health often rely on samples taken by venous blood draws at health care centers. In a study published in Communications medicine, researchers from KTH, Karolinska Institute, and the University of Gothenburg instead used a home sampling device to collect dried blood spots from the general population during the COVID-19 pandemic...Read more Different expression patterns in invasive and noninvasive PitNETsIn a study published in the Journal of the Endocrine Society, transcriptomics analysis and radiological evaluation was used to explore the differences between invasive and noninvasive pituitary neuroendocrine tumors (PitNETs) with respect to parasellar growth, bone invasiveness and vascularization...Read more Altered plasma protein profiles in genetic FTDIn a study published in Molecular Neurodegeneration an international group of scientists including researchers from KTH have used a multiplex plasma profiling assay and a well-described genetic frontotemporal dementia (FTD) cohort collected within the GENFI study to explore potential plasma biomarkers that could reflect the pathology of this disease...Read more The roles of vaccine-induced SARS-CoV-2 NAbs and T cells in protection and diseaseIn a study published in Molecular Therapy researchers from KTH among others have generated several different DNA vaccines selectively activating neutralizing antibodies (Nabs) and/or T cells and used them in different animal models to study their individual roles in the protection against severe SARS-CoV-2...Read more |